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KMID : 0380420020260030213
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Journal of Prventive Veterinary Medicine
2002 Volume.26 No. 3 p.213 ~ p.219
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Characteristics of Mercuric Chloride-induced Hemolysis
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Abstract
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This study was examined to find out the possibility of membrane lipid peroxidation as the cause on mercuric chloride-induced hemolysis of indigenous Korean goat erythrocytes. In 0.03% erythrocyte suspension treated with 2 10 M of HgCl₂, hemolysis tended to occur HgCl₂-dependently. Temporary resistance on HgCl₂-induced hemolysis was shown in all groups 15 minutes later which is different from that on H₂O₂ treated hemolysis. Changes of thiobarbituric acid(TBA) value and fluorescence intensity were measured to investigate the possibility of lipid peroxidation in 2 20% hemolytic groups of HgCl₂-treated 4% erythrocyte suspension. There were not only no changes of TBA value rated as lipid peroxidation by H₂O₂, but also even decrement of fluorescence intensity. These results suggest that HgCl₂^(-) induced hemolysis is not related to membrane lipid peroxidation.
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